The iConquerMS™ initiative enables the collection of extremely large amounts of information required for research, and research is essential for answering key questions about MS. Unlike other data-gathering projects, iConquerMS™ is driven by individuals with MS, and is informed by their input and ideas. iConquerMS™ is also important because it is among the first examples of a ‘large-scale approach’ to research, an approach many believe is essential to tackle the complexities of disease effectively.